Estimating linkage disequilibrium from genotypes under Hardy-Weinberg equilibrium
نویسندگان
چکیده
منابع مشابه
A Bayesian characterization of Hardy-Weinberg disequilibrium.
A Bayesian method for determining if there are large departures from independence between pairs of alleles at a locus, Hardy-Weinberg equilibrium (HWE), is presented. We endorse the view that a population will never be exactly in HWE and that there will be occasions when there is a need for an alternative to the usual hypothesis-testing setting. Bayesian methods provide such an alternative, and...
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Hardy-Weinberg equilibrium (HWE) holds when, in a closed population with random mating and without mutation and natural selection, genotype frequencies at any locus is a simple function of allele frequencies. Testing for HWE is now a common practice in population genetics and genetic association studies of non-communicable diseases; however, it is less-regarded, or sometimes miss-interpreted, i...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2020
ISSN: 1471-2156
DOI: 10.1186/s12863-020-0818-9